The global incidence of AS is 0.25% to 0.45%, and is 0.3% in China. The discs wedging contributes more to the thoracolumbar kyphosis in patients with GK < 70° than vertebral wedging, whereas vertebral wedging is more conducive to the thoracolumbar kyphosis in patients with GK ≥ 70°, indicating different biomechanical pathogenesis in varied severity of thoracolumbar kyphosis secondary to AS.Īnkylosing spondylitis (AS) is a systematic rheumatic disorder, which is characterized clinically by pain and stiffness of the back, and radiologically by arthritic changes in the sacroiliac joints and the entire spine. Various disc and vertebral wedging exist in thoracolumbar kyphosis secondary to AS. Additionally, correlation analysis revealed a significant correlation between the apical vertebral wedging angle and GK ( R = 0.850, P = 0.001). The wedging of vertebrae was significantly higher in group B than in group A (50.1° ± 5.1° vs 26.7° ± 2.7°, P < 0.01). The wedging angle and wedging percentage of discs were significantly higher than those of vertebrae in group A (34.8° ± 2.5° vs 26.7° ± 2.7°, P < 0.01 and 56.6% vs 43.4%, P < 0.01), whereas disc wedging and disc wedging percentage were significantly lower than vertebrae in group B (37.6° ± 7.0° vs 50.1° ± 5.1°, P < 0.01 and 42.7% vs 57.3%, P < 0.01). With respect to the mean disease duration, significant difference was observed between the two groups ( P < 0.01). The duration of disease and sex were also recorded in this study. The correlation between the apical vertebral wedging angle and GK was calculated by Pearson correlation analysis. Intergroup and intragroup comparisons were subsequently performed to investigate the different contributions of disc and vertebra to the GK. The wedging angle of each disc and vertebra comprising the thoracolumbar kyphosis was measured, and the proportion of the wedging angle to the GK was calculated accordingly. Each GK was divided into disc wedge angles and vertebral wedge angles. Based on global kyphosis (GK), 26 patients with GK < 70° were assigned to group A, and the other 33 patients with GK ≥ 70° were included in group B. The objective of this study was to compare different contributions of vertebral and disc wedging to the thoracolumbar kyphosis in AS patients, and to analyze the relationship between the apical vertebral wedging angle and thoracolumbar kyphosis.įrom October 2009 to October 2013, a total of 59 consecutive AS patients with thoracolumbar kyphosis with a mean age of 38.1 years were recruited in this study. However, their relative contribution to thoracolumbar kyphosis is not fully understood. Both vertebral body wedging and disc wedging are found in ankylosing spondylitis (AS) patients with thoracolumbar kyphosis.
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